PLAS-GEN Blood Substitute 4-9-2022 Glenn Mouser Stated Issue In recent years the world’s blood shortage has propelled biotechnology in search of functional blood substitutes. With little success. Typically, with trauma or acute blood loss the emergency patient is field treated with blood transfusions. There are inherent issues with this approach. Non-matching blood type, blood borne pathogens, not to mention availability. An alternative is saline solution blood/plasma expander. However, this approach is limited.
Resolve Enter PlasGen, a functional solution. PlasGen blood substitute does not contain blood derivation products. No blood plasma, red and white cells, or platelets of human or animal blood, but functions to transport and deliver oxygen to the body's tissues. In addition to carrying oxygen, such compounds are sterilized against infectious diseases.
PlasGen is a possible patentable concept for plasma expanders. Typical expanders do little more than dilute the remaining blood and do not assist in providing life-sustaining, critically-needed oxygen.
Process The 'secret' of PlasGen’s possible patent-pending expander is in the water. It is a very special energy water. The water starts out as USP Pharmaceutical Grade Water. Then it is treated in a very special way that is extremely time and energy intensive. At this point, the total-organic-carbons are virtually non-existent. The process renders the water in such a way as to remove any disease markers. This will allow for an easy release of the oxygen.
A proprietary blend of other ingredients act as a catalyst. Then the water molecule breaks apart and releases the oxygen into the blood stream via the lungs. A very special and proprietary stem cell extract, prepared in a unique process, is also an important part of the formula. It is further enhanced with a proprietary all-natural ingredient that synergistically increases the efficacy of the stem cell extract by up to 7500%.
PlasGen is more than just a saline solution or a plasma expander. By mixing PlasGen with our lyophilized donor blood (explained below) that is packaged in a unique way, a fresh and ready-to-use super-oxygenated plasma expander that mimics blood very closely will course throughout the patient’s body, supplying much needed, life-sustaining oxygen thereby increasing red blood cell growth and clotting. The main ingredients are carbon, hydrogen and oxygen.
Storage The storage requirements for PlasGen are easier and more flexible than the storage requirements of human blood. Human blood must be refrigerated or frozen and lasts no more than a few weeks. Thus, another potential advantage of employing PlasGen addresses the donor blood shortage crisis. Because this product does not use human or animal blood or blood fractions, it extends shelf life, eliminates blood typing, and stops blood-borne pathogen issues.
lREAL WORLD APPLICATION A lyophilized (freeze-dried) whole blood product and delivery system known as PlasGen is the actual real-world application of PlasGen. The use of whole blood as a resuscitation fluid, according to early U.S. Army studies, has shown to significantly reduce battlefield mortality. In many situations, use of fresh frozen plasma or whole human blood is limited by storage requirements and the short shelf-life for thawed whole blood. The PlasGen product and delivery system will offer individual units of single source donor lyophilized whole blood that are safe and easy to carry, reconstitute and administer.
A battlefield soldier could easily carry the equivalent of 2 or 3 units of his own whole blood. It would be our lyophilized (freeze-dried) blood. It would have already been dosed into our frangible seal IV bag. The weight of each bag would be approx. 3.5 ounces. In the event of a trauma injury, a field medic would assess the situation and may determine that a blood transfusion is needed to sustain the soldier’s life. The medic simply retrieves the IV bag with the lyophilized blood from the soldiers pack, validates the soldier's ID to the dried blood bag contents with our unique software and scanner (it is also human readable) , adds a unit dose of the PlasGen blood substitute oxygenated plasma, that is carried in large quantities by the medic team, twists the bag to break the frangible seal, mixes it for 1 minute and in less than 2 minutes the soldier is receiving a unit or more of his own whole blood.
Success Leveraging a core competency in lyophilization will improve battlefield and civilian care. Success of the PlasGen process on the battlefield could mean improved care for civilians. Responsible for more than 500,000 deaths annually, the National Trauma Institute reports that trauma is the leading cause of death in the U.S. for individuals ages one to 44. The PlasGen products and delivery system that is readily available at the point of care could significantly decrease mortality for these patients. Another advantage is the ability to reconstitute in less than 2 minutes; where waiting 20 minutes for fresh frozen plasma or whole blood to thaw – may be the difference between life and death. This is a crucial initiative, developing a lyophilized human plasma product and delivery system will be a significant evolution for battlefield and civilian trauma care. As the use of PlasGen carries into the civilian medical space, we will see increased survival rates in patients treated at smaller hospitals and numerous trauma centers where currently, fresh frozen plasma or whole blood is not readily available.
Market The value of the global blood industry was nearly $300 billion. Regulatory It would likely be marketed as a blood / plasma expander rather than a blood substitute. The FDA CFRs are already in place. A few FDA medical device approvals will be needed. Process There are several profit centers of this project. Each one has tremendous potential. They can each be licensed to other companies.. Each of the projects will require medical, bio-science, and legal research to acquire patents. the plasma expander the freeze-dried blood the ID software the scanner system the delivery IV bag system the marketing and packaging many more
Artificial Skin
This is an artificial skin that is used as a delivery system of drugs, medicine, actives, and other applications. This is not a spray-on type bandage. It does not stop the bleeding, rather it allows trans-dermal delivery and protection to the skin. It is designed to replace skin transplants for scrape and burn victims. It is painless, and leaves no scarring. The main ingredients are carbon, hydrogen and oxygen.
The delivery system is thin sheets of a paper-like matrix. It dries to a thin, invisible matrix. It remains flexible to bend with the skin. It remains somewhat moist to allow the 'actives' to continue delivering.
TRAU-MEND... WOUND HEALING
TRAU-MEND End the hemorrhaging of trauma.
Homeostasis and sealing of bleeding tissue during laparoscopy biopsy procedures. Trau-Mend is applied with the same needle (and simultaneously) used for biopsy.
Sampling of cells or tissue
During lung biopsy the lungs may collapse
During surgical biopsy (including but not limited to the heart, spleen, lungs and liver), excessive bleeding often occurs. Many bio-compatible processes are required to be used to manage these issues. Trau-Mend provides a manageable novel solution to control blood loss during surgery and biopsy procedures by managing the blood loss during surgery. Trau-Mend will biodegrade after the wounds have healed.
Trau-Mend may be used to enhance suturing during surgery. It will bond with the skin, suture material and fill the holes caused by suturing. Thus allowing a previously unheard level of control of bleeding.
Trau-Mend is a spray. Applied by saturating the area. The seal forms in a few seconds. The 'dirtier' the wound / area is the better it works.